Across TCGA pan-cancer cohorts, MIR548Z RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR548Z’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR548Z RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR548Z is over-expressed in tumor.
LUSC are the cancer types where MIR548Z tumor–normal differential expression is most reproducible.