PPP1R2C

Across TCGA patient cohorts, PPP1R2C mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R2C-associated genes across cancer lineages are MTA2, LSM14B, and SLC25A4. Each is linked with PPP1R2C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R2C-to-partner and partner-to-PPP1R2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTA2 grouped by PPP1R2C-low versus PPP1R2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R2C→partner) and Y-score (partner→PPP1R2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTA2 →	+0.744	+3.386	<.001	.004	3	1
UCEC	LSM14B →	+0.666	+3.332	.002	.005	3	1
UCEC	SLC25A4 →	+0.732	+3.332	.001	.005	3	1
UCEC	MRPL17 →	+0.467	+3.343	.003	.005	3	1
UCEC	LZIC →	+0.773	+3.332	.001	.005	3	1
UCEC	C4orf3 →	+0.696	+3.354	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

MTA2 by PPP1R2C expression — UCEC

Explore this box plot interactively →