PPP1R2C

Across TCGA pan-cancer cohorts, PPP1R2C RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PPP1R2C data layer compared with 1 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PPP1R2C RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPP1R2C expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, HNSC, and CESC are the cancer types where PPP1R2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.537	0.311	<.001	68	view →
HNSC	DFS	Tertile	II,III,IV	0.537	0.700	.005	59	view →
CESC	OS	Tertile	All	0.891	0.752	.007	42	view →
UCS	DFS	Tertile	IV	0.192	0.776	<.001	36	view →
STAD	OS	Tertile	II,III,IV	0.682	0.363	.011	30	view →
ACC	DFS	Tertile	II,III,IV	0.252	0.765	<.001	27	view →
LUAD	DFS	Tertile	II,III,IV	0.583	0.325	.012	20	view →
COAD	DFS	Tertile	II,III,IV	0.933	0.464	.018	18	view →
THCA	DFS	Tertile	II,III,IV	0.145	0.794	.001	18	view →
LIHC	OS	Tertile	III,IV	0.171	0.623	.002	18	view →
PRAD	OS	Tertile	All	0.944	0.995	.002	18	view →
PAAD	OS	Tertile	III,IV	0.558	0.924	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PPP1R2C–SKCM (OS)

Open the SKCM breakdown →