PPP1R1C

Across TCGA patient cohorts, PPP1R1C RNA expression is significantly associated with the go_rna of many other GO terms, with 7,050 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PPP1R1C-associated GO terms across cancer lineages are Nuclear envelope organization, COPII-coated vesicle budding, and Mitotic nuclear membrane organization. Each is linked with PPP1R1C in more than 12 cancer types. Because this analysis shows association rather than direction, both PPP1R1C-to-partner and partner-to-PPP1R1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear envelope organization grouped by PPP1R1C-low versus PPP1R1C-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1C→partner) and Y-score (partner→PPP1R1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Nuclear envelope organization →	+0.037	+0.414	<.001	<.001	3	13
UVM	COPII-coated vesicle budding →	+0.041	+0.489	.001	<.001	3	12
UVM	Mitotic nuclear membrane organization →	+0.049	+0.435	<.001	<.001	3	12
UCS	Regulation of ubiquitin-dependent protein catabolic process →	+0.038	+0.481	<.001	.009	2	13
STAD	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.036	+0.307	<.001	.003	3	12
STAD	Nucleoside salvage →	+0.039	+0.400	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,050 associations by consensus.

Nuclear envelope organization by PPP1R1C expression — UVM

Explore this box plot interactively →