PPP1R1C

Across TCGA pan-cancer cohorts, PPP1R1C RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PPP1R1C data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher PPP1R1C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R1C expression acts as an unfavorable survival marker, although some lineages such as THYM and UCS show a favorable association.

STAD, BLCA, and LGG are the cancer types where PPP1R1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.564	0.734	.001	104	view →
BLCA	OS	Median	All	0.219	0.549	<.001	93	view →
LGG	OS	Median	All	0.726	0.887	<.001	38	view →
COAD	DFS	Quartile	IV	0.243	0.552	.001	35	view →
THYM	DFS	Tertile	II,III,IV	0.963	0.660	.011	30	view →
LUAD	OS	Median	All	0.625	0.767	.007	29	view →
KICH	OS	Quartile	All	0.686	1.000	.009	26	view →
UCEC	DFS	Median	All	0.545	0.767	.015	14	view →
LUSC	DFS	Median	III,IV	0.497	0.751	.006	13	view →
UCS	DFS	Tertile	II,III,IV	0.512	0.170	.022	12	view →
PRAD	DFS	Tertile	All	0.937	0.863	.021	10	view →
THCA	OS	Median	All	1.000	0.798	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PPP1R1C–STAD (DFS)

Open the STAD breakdown →