PPP1R1C

Across TCGA pan-cancer cohorts, PPP1R1C RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PPP1R1C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP1R1C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R1C is over-expressed in tumor, although a few such as KIRC and LIHC show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where PPP1R1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.023	<.001	12	view →
BLCA	All	All	+0.716	<.001	8	view →
KIRC	Male	II,III,IV	−0.543	<.001	8	view →
THCA	All	All	+0.742	<.001	6	view →
LIHC	All	All	−0.525	.001	4	view →
BRCA	Female	II,III,IV	+0.233	.009	4	view →
STAD	All	All	+0.410	.014	3	view →
KIRP	All	All	−0.312	.002	3	view →
LUAD	All	IV	−1.235	.001	2	view →
PAAD	All	All	+1.095	.003	2	view →
PRAD	All	All	−0.433	<.001	2	view →
COAD	All	All	+0.143	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PPP1R1C–HNSC

Open the HNSC breakdown →