PPP1R1C

Across TCGA patient cohorts, PPP1R1C protein abundance is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPP1R1C-associated genes across cancer lineages are SEZ6L, ISM2, and BMP7. Each is linked with PPP1R1C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R1C-to-partner and partner-to-PPP1R1C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1R1C versus SEZ6L in GBM, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1C→partner) and Y-score (partner→PPP1R1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEZ6L →	+1.091	+0.453	.004	.009	3	1
GBM	ISM2 →	-0.268	-0.596	.003	.009	3	1
GBM	BMP7 →	+0.990	+0.734	<.001	<.001	3	1
GBM	PLA2G15 →	-0.408	-0.668	.001	.001	3	1
GBM	NCALD →	+0.660	+0.571	.008	.008	3	1
GBM	JAK3 →	-0.511	-0.509	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

PPP1R1C vs SEZ6L — GBM

Explore this scatter interactively →