PPP1R1C

Across TCGA patient cohorts, PPP1R1C mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R1C-associated genes across cancer lineages are RN7SL649P, H4C7, and MIR3661. Each is linked with PPP1R1C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R1C-to-partner and partner-to-PPP1R1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL649P grouped by PPP1R1C-low versus PPP1R1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1C→partner) and Y-score (partner→PPP1R1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL649P →	+0.391	+3.474	<.001	.006	3	2
COAD	H4C7 →	+0.167	+5.602	.006	.004	3	2
SKCM	MIR3661 →	+0.342	+4.208	<.001	.003	3	2
UCEC	FRG2C →	+0.233	+4.043	.001	.001	3	1
UCEC	PROP1 →	+0.291	+3.518	.004	.007	3	1
UCEC	CBLL2 →	+0.165	+4.545	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

RN7SL649P by PPP1R1C expression — UCEC

Explore this box plot interactively →