PPP1R1A

Across TCGA patient cohorts, PPP1R1A protein abundance is significantly associated with the RNA expression of many other genes, with 8,676 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPP1R1A-associated genes across cancer lineages are MYOM1, CHRDL1, and PYGM. Each is linked with PPP1R1A in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP1R1A-to-partner and partner-to-PPP1R1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1R1A versus MYOM1 in HNSC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1A→partner) and Y-score (partner→PPP1R1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYOM1 →	+1.260	+0.498	<.001	<.001	3	4
BRCA	CHRDL1 →	+1.482	+0.698	<.001	<.001	3	4
HNSC	PYGM →	+1.372	+0.547	<.001	<.001	3	4
GBM	DLG2 →	+0.592	+0.532	<.001	<.001	3	4
GBM	TF →	+1.395	+0.594	<.001	<.001	3	4
GBM	HHATL →	+0.971	+0.601	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,676 associations by consensus.

PPP1R1A vs MYOM1 — HNSC

Explore this scatter interactively →