PPP1R1A

Across TCGA pan-cancer cohorts, PPP1R1A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PPP1R1A data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PPP1R1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R1A expression acts as an unfavorable survival marker, although some lineages such as LGG and DLBC show a favorable association.

UVM, KIRC, and UCEC are the cancer types where PPP1R1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.371	0.765	<.001	126	view →
KIRC	OS	Median	All	0.533	0.724	<.001	122	view →
UCEC	OS	Median	All	0.572	0.756	<.001	76	view →
LGG	DFS	Median	All	0.811	0.663	<.001	54	view →
DLBC	DFS	Tertile	All	1.000	0.305	.003	52	view →
COAD	DFS	Tertile	All	0.716	0.826	<.001	44	view →
THCA	OS	Median	III,IV	0.946	1.000	.006	39	view →
PAAD	DFS	Median	All	0.366	0.194	<.001	37	view →
KIRP	OS	Tertile	III,IV	0.779	0.316	.004	34	view →
LUSC	OS	Quartile	All	0.304	0.472	.013	34	view →
LIHC	DFS	Quartile	All	0.505	0.324	.005	19	view →
SCLC	DFS	Median	II,III,IV	0.205	0.819	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PPP1R1A–UVM (DFS)

Open the UVM breakdown →