PPP1R1A

Across TCGA pan-cancer cohorts, PPP1R1A RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PPP1R1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PPP1R1A RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R1A is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and HNSC are the cancer types where PPP1R1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−7.490	<.001	11	view →
KIRC	Male	II,III,IV	−3.955	<.001	11	view →
HNSC	Male	IV	−3.075	<.001	9	view →
COAD	Male	All	−1.605	<.001	9	view →
BRCA	All	III,IV	−4.414	<.001	8	view →
LIHC	All	II,III,IV	−2.168	<.001	8	view →
BLCA	All	III,IV	−1.856	.004	8	view →
STAD	All	All	−2.391	<.001	7	view →
THCA	All	All	−0.477	<.001	7	view →
KIRP	Male	All	−1.968	<.001	6	view →
CHOL	All	All	−4.005	<.001	5	view →
READ	All	All	−2.790	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PPP1R1A–KICH

Open the KICH breakdown →