PPP1R1A

Across TCGA patient cohorts, PPP1R1A mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R1A-associated genes across cancer lineages are MIR760, MIR6839, and PRNT. Each is linked with PPP1R1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R1A-to-partner and partner-to-PPP1R1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR760 grouped by PPP1R1A-low versus PPP1R1A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1A→partner) and Y-score (partner→PPP1R1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR760 →	+0.557	+3.641	.004	.008	3	2
UCEC	MIR6839 →	+0.293	+3.077	<.001	.009	3	1
CESC	PRNT →	+0.021	+5.201	.005	.007	3	1
CESC	MRPL32P1 →	+0.178	+6.569	<.001	.001	3	1
SKCM	MIR6893 →	+0.352	+3.622	<.001	.005	3	1
UCEC	RNU6-1005P →	+0.504	+2.843	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

MIR760 by PPP1R1A expression — SKCM

Explore this box plot interactively →