PPP1R1A

Across TCGA cell cohorts, PPP1R1A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,423 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPP1R1A-associated GO terms across cancer lineages are Establishment of RNA localization, Regulation of potassium ion transmembrane transport, and Regulation of potassium ion transport. Each is linked with PPP1R1A in more than 7 cancer types. Because this analysis shows association rather than direction, both PPP1R1A-to-partner and partner-to-PPP1R1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of RNA localization grouped by PPP1R1A-low versus PPP1R1A-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1A→partner) and Y-score (partner→PPP1R1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Establishment of RNA localization →	+0.047	+0.119	<.001	<.001	3	8
BONE	Regulation of potassium ion transmembrane transport →	-0.160	-4.796	<.001	<.001	3	8
BONE	Regulation of potassium ion transport →	-0.146	-4.293	<.001	.002	3	8
BONE	Epigenetic regulation of gene expression →	+0.088	+4.378	<.001	.002	3	7
BONE	Regulation of DNA-templated transcription elongation →	+0.091	+4.322	.002	.002	3	7
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.133	+4.426	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,423 associations by consensus.

Establishment of RNA localization by PPP1R1A expression — BLOOD_Leukemia

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