PPP1R1A

Across TCGA cell cohorts, PPP1R1A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R1A-associated genes across cancer lineages are RFPL3, FCGR3B, and KRTAP10-1. Each is linked with PPP1R1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R1A-to-partner and partner-to-PPP1R1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by PPP1R1A-low versus PPP1R1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1A→partner) and Y-score (partner→PPP1R1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFPL3 →	+0.058	+4.095	<.001	.009	3	1
LARGE_INTESTINE	FCGR3B →	+0.174	+4.467	<.001	.004	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR5V1 →	+0.010	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RFPL3 by PPP1R1A expression — LARGE_INTESTINE

Explore this box plot interactively →