PPP1R12C

Across TCGA patient cohorts, PPP1R12C mutation is significantly associated with the RNA expression of many other genes, with 4,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R12C-associated genes across cancer lineages are RNU6-32P, RNA5SP467, and MTND4LP19. Each is linked with PPP1R12C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R12C-to-partner and partner-to-PPP1R12C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-32P grouped by PPP1R12C-low versus PPP1R12C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12C→partner) and Y-score (partner→PPP1R12C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-32P →	+0.795	+3.159	<.001	.006	3	2
COAD	RNA5SP467 →	+0.214	+3.374	.004	.008	3	2
COAD	MTND4LP19 →	+0.150	+4.225	.003	.007	3	2
COAD	TPMTP4 →	+0.050	+5.087	<.001	.002	3	2
COAD	HCFC1-AS1 →	+0.412	+3.809	<.001	.003	3	2
COAD	LINC00904 →	+0.070	+4.225	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,067 associations by consensus.

RNU6-32P by PPP1R12C expression — COAD

Explore this box plot interactively →