PPP1R12C

Across TCGA pan-cancer cohorts, PPP1R12C RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PPP1R12C’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PPP1R12C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R12C is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

LIHC, HNSC, and BLCA are the cancer types where PPP1R12C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R12C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.186	<.001	9	view →
HNSC	All	All	+0.332	<.001	9	view →
BLCA	Male	III,IV	−2.182	<.001	8	view →
LUAD	Male	All	−0.941	<.001	8	view →
COAD	All	II,III,IV	−0.469	<.001	7	view →
UCEC	All	All	−1.121	<.001	6	view →
BRCA	All	All	−0.505	<.001	6	view →
CHOL	All	All	+1.530	<.001	5	view →
LUSC	All	All	−0.719	<.001	5	view →
KICH	All	All	−0.691	<.001	5	view →
THCA	Female	All	−0.260	.001	5	view →
KIRC	All	All	+0.250	.003	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PPP1R12C–LIHC

Open the LIHC breakdown →