PPP1R12A

Across TCGA cell cohorts, PPP1R12A mutation is significantly associated with the mutation status of many other genes, with 3,764 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R12A-associated genes across cancer lineages are LRP4, KNL1, and TMPRSS9. Each is linked with PPP1R12A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R12A-to-partner and partner-to-PPP1R12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRP4 grouped by PPP1R12A-low versus PPP1R12A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12A→partner) and Y-score (partner→PPP1R12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LRP4 →	+3.440	+3.784	<.001	<.001	1	3
CNS	KNL1 →	+3.025	+3.139	.009	.009	1	3
CNS	TMPRSS9 →	+4.347	+3.862	.001	.001	1	3
CNS	SH2D3C →	+4.347	+3.862	.001	.001	1	3
LUNG_NSCLC_LUAD	C19orf44 →	+4.339	+5.303	<.001	<.001	1	3
BLOOD_Leukemia	ZMIZ1 →	+2.894	+4.432	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,764 associations by consensus.

LRP4 by PPP1R12A expression — CNS

Explore this box plot interactively →