PPP1R12A

Across TCGA pan-cancer cohorts, PPP1R12A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PPP1R12A data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PPP1R12A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP1R12A expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UCS, KIRC, and UVM are the cancer types where PPP1R12A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.500	0.192	.008	44	view →
KIRC	DFS	Tertile	All	0.836	0.533	<.001	43	view →
UVM	DFS	Quartile	III,IV	0.170	0.848	<.001	42	view →
MESO	DFS	Median	All	0.289	0.432	.008	26	view →
SKCM	OS	Quartile	All	0.409	0.326	.004	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LIHC	OS	Median	All	0.711	0.839	<.001	22	view →
BRCA	DFS	Median	III,IV	0.926	0.821	.003	20	view →
ACC	DFS	Quartile	II,III,IV	0.442	0.835	.002	19	view →
SCLC	OS	Tertile	II,III,IV	0.844	0.496	.008	19	view →
KICH	DFS	Median	II,III,IV	0.581	0.920	.007	16	view →
LUSC	DFS	Median	III,IV	0.512	0.914	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PPP1R12A–UCS (DFS)

Open the UCS breakdown →