PPM1H

Across TCGA patient cohorts, PPM1H mutation is significantly associated with the RNA expression of many other genes, with 3,915 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1H-associated genes across cancer lineages are RNA5SP412, H3P17, and MIR5100. Each is linked with PPM1H in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1H-to-partner and partner-to-PPM1H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by PPM1H-low versus PPM1H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1H→partner) and Y-score (partner→PPM1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.606	+2.049	<.001	.001	3	3
HNSC	H3P17 →	+0.176	+5.578	<.001	.004	3	3
LUAD	MIR5100 →	+0.155	+5.535	<.001	<.001	3	3
SKCM	MIR515-2 →	+0.101	+4.219	<.001	.006	3	3
BRCA	RN7SL470P →	+0.295	+4.607	<.001	.004	3	2
LIHC	MIR648 →	+0.293	+3.479	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,915 associations by consensus.

RNA5SP412 by PPM1H expression — UCEC

Explore this box plot interactively →