PPM1H

Across TCGA pan-cancer cohorts, PPM1H RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PPM1H’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPM1H RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPM1H is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where PPM1H tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1H RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+2.074	<.001	12	view →
KIRC	Male	II,III,IV	−2.176	<.001	11	view →
LUAD	Male	III,IV	+1.843	<.001	8	view →
STAD	Male	All	+1.718	<.001	8	view →
UCEC	All	All	+1.415	<.001	6	view →
BLCA	All	III,IV	+1.380	.003	6	view →
BRCA	All	II,III,IV	+0.887	<.001	6	view →
READ	Female	All	+2.246	<.001	5	view →
THCA	All	IV	−0.950	.006	4	view →
CHOL	Male	All	+2.746	<.001	3	view →
PRAD	All	All	+1.096	<.001	2	view →
LUSC	Female	All	+0.865	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PPM1H–COAD

Open the COAD breakdown →