PPM1H

Across TCGA pan-cancer cohorts, PPM1H RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PPM1H data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPM1H RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1H expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, THYM, and UCS are the cancer types where PPM1H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.893	0.731	.002	70	view →
THYM	OS	Tertile	All	0.874	1.000	.007	37	view →
UCS	DFS	Median	II,III,IV	0.281	0.580	.010	34	view →
HNSC	DFS	Median	IV	0.717	0.563	.002	32	view →
LAML	DFS	Tertile	All	0.611	0.330	<.001	30	view →
SKCM	OS	Tertile	All	0.261	0.416	<.001	27	view →
KICH	OS	Tertile	II,III,IV	0.504	0.934	.009	26	view →
THCA	OS	Median	II,III,IV	0.326	1.000	.002	23	view →
CHOL	DFS	Tertile	II,III,IV	0.198	0.607	.006	23	view →
UVM	OS	Quartile	III,IV	0.500	1.000	.010	21	view →
OV	DFS	Median	All	0.194	0.129	.013	18	view →
PAAD	DFS	Quartile	All	0.413	0.143	.028	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PPM1H–UCEC (DFS)

Open the UCEC breakdown →