PPM1H

Across TCGA patient cohorts, PPM1H mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1H-associated genes across cancer lineages are 4E-BP1, mTOR_pS2448, and PCNA. Each is linked with PPM1H in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1H-to-partner and partner-to-PPM1H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PPM1H-low versus PPM1H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1H→partner) and Y-score (partner→PPM1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.518	+3.730	<.001	<.001	3	3
UCEC	mTOR_pS2448 →	-0.155	-1.986	.008	.029	3	2
UCEC	PCNA →	+0.295	+3.584	<.001	.002	3	2
UCEC	Cyclin-B1 →	+0.758	+3.169	<.001	<.001	3	2
UCEC	FASN →	+0.414	+2.000	.007	.010	3	1
UCEC	FOXO3a →	-0.089	-2.986	.025	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

4E-BP1 by PPM1H expression — UCEC

Explore this box plot interactively →