PPM1H

Across TCGA cell cohorts, PPM1H mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPM1H-associated genes across cancer lineages are ITGAD, GTSF1L, and CPXCR1. Each is linked with PPM1H in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1H-to-partner and partner-to-PPM1H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by PPM1H-low versus PPM1H-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1H→partner) and Y-score (partner→PPM1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITGAD →	+0.120	+4.199	<.001	.007	3	2
BLOOD_Leukemia	GTSF1L →	+0.792	+3.619	<.001	.007	3	1
BLOOD_Leukemia	CPXCR1 →	+0.063	+3.971	.002	.002	3	1
BLOOD_Leukemia	SSX5 →	+0.247	+3.968	.001	.002	3	1
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+3.614	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ITGAD by PPM1H expression — BREAST

Explore this box plot interactively →