PPM1E

Across TCGA patient cohorts, PPM1E RNA expression is significantly associated with the protein abundance of many other proteins, with 15,072 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPM1E-associated proteins across cancer lineages are MYEF2, SEPTIN3, and TNKS1BP1_S1297. Each is linked with PPM1E in more than 5 cancer types. Because this analysis shows association rather than direction, both PPM1E-to-partner and partner-to-PPM1E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPM1E versus MYEF2 in HNSC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1E→partner) and Y-score (partner→PPM1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYEF2 →	+0.858	+0.624	.001	.007	2	6
CCRCC	SEPTIN3 →	+0.994	+0.403	.004	.002	3	5
LSCC	TNKS1BP1_S1297 →	-0.574	-0.590	.001	.007	3	4
GBM	MESD →	-0.257	-0.946	<.001	<.001	3	4
HNSC	PPP1R13L →	-0.464	-0.548	<.001	.001	3	4
HNSC	MYEF2_S17 →	+0.998	+0.711	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,072 associations by consensus.

PPM1E vs MYEF2 — HNSC

Explore this scatter interactively →