PPM1E

Across TCGA pan-cancer cohorts, PPM1E RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PPM1E’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPM1E RNA is repressed in tumor relative to normal tissue. In most cancer types PPM1E is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where PPM1E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	−1.278	<.001	12	view →
BRCA	All	II,III,IV	+0.701	<.001	6	view →
COAD	Female	All	−0.157	.001	5	view →
READ	All	All	−0.190	.010	4	view →
LUSC	All	III,IV	−0.346	.031	3	view →
PRAD	All	All	+1.603	<.001	2	view →
LIHC	All	All	+0.495	.001	2	view →
LUAD	Female	III,IV	−0.350	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PPM1E–KIRC

Open the KIRC breakdown →