PPM1E

Across TCGA pan-cancer cohorts, PPM1E RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PPM1E data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PPM1E RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPM1E expression acts as an unfavorable survival marker, although some lineages such as PAAD and KIRC show a favorable association.

UVM, ACC, and PAAD are the cancer types where PPM1E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.368	0.819	<.001	110	view →
ACC	DFS	Quartile	All	0.259	0.759	.001	41	view →
PAAD	DFS	Tertile	All	0.426	0.202	<.001	37	view →
STAD	DFS	Tertile	All	0.278	0.490	.006	34	view →
THCA	OS	Median	III,IV	0.940	1.000	.002	33	view →
KIRP	DFS	Tertile	IV	0.036	0.765	.010	30	view →
READ	DFS	Median	All	0.750	0.919	.010	19	view →
PCPG	DFS	Quartile	All	0.569	0.936	.011	17	view →
KIRC	DFS	Quartile	All	0.867	0.747	.025	8	view →
ESCA	DFS	Tertile	All	0.375	0.544	.025	8	view →
LUSC	OS	Median	II,III,IV	0.285	0.503	.026	8	view →
PRAD	DFS	Tertile	All	0.888	0.736	.033	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PPM1E–UVM (DFS)

Open the UVM breakdown →