PPM1E

Across TCGA patient cohorts, PPM1E protein abundance is significantly associated with the RNA expression of many other genes, with 7,964 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPM1E-associated genes across cancer lineages are ARHGAP5, PPP2R1A, and FSD1L. Each is linked with PPM1E in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1E-to-partner and partner-to-PPM1E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPM1E versus ARHGAP5 in LUAD, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1E→partner) and Y-score (partner→PPM1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGAP5 →	+0.653	+0.810	.009	.001	3	2
LUAD	PPP2R1A →	+0.500	+0.967	.003	.004	3	2
BRCA	FSD1L →	+0.647	+0.875	.005	.008	3	2
BRCA	RIC8B →	+0.357	+0.713	.002	<.001	3	2
BRCA	ACVR2B →	+0.521	+0.852	.003	.003	3	2
BRCA	GRIA2 →	+2.106	+1.074	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,964 associations by consensus.

PPM1E vs ARHGAP5 — LUAD

Explore this scatter interactively →