PPM1E

Across TCGA patient cohorts, PPM1E mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1E-associated genes across cancer lineages are Caspase-7-cleavedD198, cIAP, and eIF4E. Each is linked with PPM1E in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1E-to-partner and partner-to-PPM1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PPM1E-low versus PPM1E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1E→partner) and Y-score (partner→PPM1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.847	+2.412	<.001	<.001	3	3
UCEC	cIAP →	+0.088	+1.594	.035	.010	3	3
UCEC	eIF4E →	+0.194	+1.947	.002	<.001	3	2
UCEC	mTOR_pS2448 →	-0.121	-2.050	.007	.001	3	2
UCEC	Src_pY527 →	-0.341	-2.584	.009	.010	3	2
COAD	C-Raf →	+0.234	+2.841	.001	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by PPM1E expression — UCEC

Explore this box plot interactively →