PPM1E

Across TCGA cell cohorts, PPM1E RNA expression is significantly associated with the go_rna of many other GO terms, with 4,163 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPM1E-associated GO terms across cancer lineages are Protein-DNA complex assembly, Protein-DNA complex organization, and RNA splicing, via transesterification reactions. Each is linked with PPM1E in more than 13 cancer types. Because this analysis shows association rather than direction, both PPM1E-to-partner and partner-to-PPM1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex assembly grouped by PPM1E-low versus PPM1E-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1E→partner) and Y-score (partner→PPM1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein-DNA complex assembly →	+0.065	+1.798	.001	<.001	3	14
LUNG_SCLC	Protein-DNA complex organization →	+0.061	+1.646	.005	.001	3	14
SOFT_TISSUE	RNA splicing, via transesterification reactions →	+0.067	+0.852	<.001	<.001	3	13
LUNG_SCLC	Positive regulation of DNA repair →	+0.063	+1.412	.001	.004	3	12
LUNG_SCLC	Positive regulation of telomerase RNA localization to Cajal body →	+0.083	+1.410	.008	.004	3	12
SOFT_TISSUE	Regulation of termination of RNA polymerase II transcription →	+0.122	+0.967	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,163 associations by consensus.

Protein-DNA complex assembly by PPM1E expression — LUNG_SCLC

Explore this box plot interactively →