PPM1E

Across TCGA cell cohorts, PPM1E mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPM1E-associated genes across cancer lineages are RPL10L, TAS2R7, and C7. Each is linked with PPM1E in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1E-to-partner and partner-to-PPM1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL10L grouped by PPM1E-low versus PPM1E-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1E→partner) and Y-score (partner→PPM1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1
STOMACH	TAS2R7 →	+0.020	+5.285	<.001	.003	3	1
BLOOD_Leukemia	C7 →	+0.454	+3.607	<.001	.004	3	1
BLOOD_Leukemia	HAND1 →	+0.020	+3.408	<.001	.005	3	1
BLOOD_Leukemia	CLPSL2 →	+0.378	+2.949	<.001	.008	3	1
BLOOD_Leukemia	TEX46 →	+0.098	+3.744	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

RPL10L by PPM1E expression — SOFT_TISSUE

Explore this box plot interactively →