PPIF

Across TCGA patient cohorts, PPIF mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIF-associated genes across cancer lineages are eIF4E, eIF4G, and A-Raf_pS299. Each is linked with PPIF in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIF-to-partner and partner-to-PPIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PPIF-low versus PPIF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIF→partner) and Y-score (partner→PPIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+3.183	.028	.009	3	1
UCEC	eIF4G →	+0.368	+3.321	.006	.010	3	1
UCEC	A-Raf_pS299 →	-0.127	-2.321	.015	.034	3	1
UCEC	ERK2 →	+0.198	+2.321	.018	.034	3	1
UCEC	FoxM1 →	+0.317	+2.179	.005	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.187	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eIF4E by PPIF expression — UCEC

Explore this box plot interactively →