PPIF

Across TCGA cell cohorts, PPIF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,249 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPIF-associated GO terms across cancer lineages are Negative regulation of cellular respiration, Negative regulation of oxidative phosphorylation, and Ribosome biogenesis. Each is linked with PPIF in more than 13 cancer types. Because this analysis shows association rather than direction, both PPIF-to-partner and partner-to-PPIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cellular respiration grouped by PPIF-low versus PPIF-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIF→partner) and Y-score (partner→PPIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of cellular respiration →	+0.173	+1.015	<.001	<.001	3	14
LUNG_NSCLC_LUAD	Negative regulation of oxidative phosphorylation →	+0.204	+1.224	<.001	<.001	3	13
BONE	Ribosome biogenesis →	+0.118	+0.899	.005	.007	3	13
BLOOD_Lymphoma	Ribosome assembly →	+0.073	+0.874	<.001	<.001	3	13
URINARY_TRACT	Positive regulation of mitochondrial RNA catabolic process →	+0.162	+0.897	<.001	.002	3	12
URINARY_TRACT	Maturation of SSU-rRNA →	+0.119	+1.488	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,249 associations by consensus.

Negative regulation of cellular respiration by PPIF expression — LUNG_NSCLC_LUAD

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