PPIE

Across TCGA patient cohorts, PPIE mutation is significantly associated with the RNA expression of many other genes, with 1,263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIE-associated genes across cancer lineages are MIR132, RNA5SP411, and RNU6-23P. Each is linked with PPIE in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIE-to-partner and partner-to-PPIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR132 grouped by PPIE-low versus PPIE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIE→partner) and Y-score (partner→PPIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR132 →	+0.220	+2.601	<.001	.005	3	2
UCEC	RNA5SP411 →	+1.015	+2.130	<.001	<.001	3	2
LUSC	RNU6-23P →	+0.464	+5.706	<.001	.003	3	2
COAD	MIR3648-2 →	+0.210	+4.225	<.001	.007	3	2
UCEC	TRAJ18 →	+0.460	+1.690	.002	.007	3	2
UCEC	LINC00363 →	+0.109	+2.857	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,263 associations by consensus.

MIR132 by PPIE expression — UCEC

Explore this box plot interactively →