PPIE

Across TCGA pan-cancer cohorts, PPIE RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPIE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPIE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIE is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where PPIE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.668	<.001	11	view →
COAD	Female	All	+0.750	<.001	10	view →
KIRC	Female	All	+0.398	<.001	10	view →
KICH	Female	II,III,IV	−1.297	<.001	9	view →
LIHC	Female	II,III,IV	+0.758	<.001	8	view →
LUAD	Female	All	+0.369	<.001	8	view →
BLCA	All	All	+0.623	.002	6	view →
LUSC	All	All	+0.512	<.001	5	view →
STAD	All	II,III,IV	+0.362	.015	4	view →
CHOL	All	All	+1.674	<.001	3	view →
KIRP	All	IV	+0.437	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPIE–HNSC

Open the HNSC breakdown →