PPIAL4G

Across TCGA patient cohorts, PPIAL4G mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PPIAL4G-associated genes across cancer lineages are OR7E105P, MIR1258, and RNU4ATAC5P. Each is linked with PPIAL4G in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIAL4G-to-partner and partner-to-PPIAL4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E105P grouped by PPIAL4G-low versus PPIAL4G-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIAL4G→partner) and Y-score (partner→PPIAL4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR7E105P →	+0.035	+3.116	<.001	.002	3	2
LUAD	MIR1258 →	+0.513	+7.930	<.001	.008	3	2
LUAD	RNU4ATAC5P →	+0.279	+7.930	<.001	.008	3	2
SKCM	KMT5A →	+0.591	+3.341	.001	.005	3	2
UCEC	RNU6-1069P →	+0.709	+3.552	<.001	<.001	3	2
UCEC	UFM1 →	+0.693	+3.606	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

OR7E105P by PPIAL4G expression — SKCM

Explore this box plot interactively →