PPIAL4G

Across TCGA pan-cancer cohorts, PPIAL4G RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPIAL4G’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPIAL4G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIAL4G is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where PPIAL4G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAL4G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.013	<.001	10	view →
HNSC	Male	II,III,IV	+0.012	.006	7	view →
LIHC	All	All	+0.006	.001	5	view →
PAAD	Female	All	−0.035	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PPIAL4G–KIRC

Open the KIRC breakdown →