PPIAL4G

Across TCGA pan-cancer cohorts, PPIAL4G RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PPIAL4G data layer compared with 1 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PPIAL4G RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPIAL4G expression acts as an unfavorable survival marker, although some lineages such as CESC and SCLC show a favorable association.

CESC, MESO, and BLCA are the cancer types where PPIAL4G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.904	0.616	<.001	92	view →
MESO	DFS	Tertile	II,III,IV	0.230	0.461	.001	50	view →
BLCA	DFS	Tertile	IV	0.273	0.565	<.001	32	view →
LIHC	DFS	Tertile	II,III,IV	0.247	0.489	.002	28	view →
ACC	OS	Quartile	II,III,IV	0.123	0.686	<.001	21	view →
KIRC	OS	Quartile	All	0.818	0.889	.026	15	view →
SCLC	OS	Median	All	0.458	0.199	.015	12	view →
KIRP	OS	Median	III,IV	0.497	0.816	.007	10	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	9	view →
TGCT	DFS	Median	All	0.885	0.740	.030	8	view →
THCA	DFS	Tertile	All	0.942	0.792	.025	7	view →
THYM	OS	Median	II,III,IV	0.875	1.000	.029	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PPIAL4G–CESC (OS)

Open the CESC breakdown →