PPIAL4E

Across TCGA patient cohorts, PPIAL4E RNA expression is significantly associated with the go_rna of many other GO terms, with 2,723 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PPIAL4E-associated GO terms across cancer lineages are Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Negative regulation of synaptic vesicle exocytosis, and L-methionine salvage from methylthioadenosine. Each is linked with PPIAL4E in more than 4 cancer types. Because this analysis shows association rather than direction, both PPIAL4E-to-partner and partner-to-PPIAL4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by PPIAL4E-low versus PPIAL4E-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIAL4E→partner) and Y-score (partner→PPIAL4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.046	+0.070	<.001	<.001	2	5
STAD	Negative regulation of synaptic vesicle exocytosis →	+0.038	+0.067	<.001	<.001	3	4
READ	L-methionine salvage from methylthioadenosine →	+0.042	+0.051	<.001	<.001	3	4
READ	Anaphase-promoting complex-dependent catabolic process →	+0.025	+0.043	<.001	<.001	3	4
STAD	tRNA 3'-end processing →	+0.027	+0.064	<.001	<.001	2	5
STAD	Meiotic cell cycle process →	+0.031	+0.068	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,723 associations by consensus.

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by PPIAL4E expression — STAD

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