PPIAL4E

Across TCGA pan-cancer cohorts, PPIAL4E RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPIAL4E’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPIAL4E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIAL4E is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

HNSC, BRCA, and PRAD are the cancer types where PPIAL4E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAL4E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+0.063	.017	2	view →
BRCA	All	III,IV	+0.043	.014	2	view →
PRAD	All	All	−0.015	.047	2	view →
ESCA	All	All	+0.152	.028	1	view →
LUSC	All	II,III,IV	+0.029	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPIAL4E–HNSC

Open the HNSC breakdown →