PPIAL4E

Across TCGA pan-cancer cohorts, PPIAL4E RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated PPIAL4E data layer.

The strongest signal is observed in mesothelioma (MESO), where higher PPIAL4E RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPIAL4E expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

MESO, COAD, and ACC are the cancer types where PPIAL4E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.052	0.528	.016	54	view →
COAD	DFS	Tertile	All	0.512	0.719	.006	36	view →
ACC	DFS	Tertile	All	0.197	0.695	<.001	30	view →
CHOL	DFS	Tertile	All	0.037	0.486	.001	18	view →
UVM	DFS	Tertile	All	0.189	0.763	.004	18	view →
THCA	DFS	Tertile	All	0.892	0.953	.013	15	view →
KIRC	DFS	Quartile	All	0.477	0.684	.020	10	view →
LUSC	DFS	Quartile	All	0.483	0.363	.014	10	view →
ESCA	OS	Tertile	II,III,IV	0.330	1.000	.022	9	view →
BRCA	OS	Tertile	II,III,IV	0.702	0.509	.030	8	view →
BLCA	DFS	Tertile	IV	0.735	0.288	.027	6	view →
CESC	DFS	Tertile	II,III,IV	0.807	0.389	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

PPIAL4E–MESO (OS)

Open the MESO breakdown →