PPIAL4E

Across TCGA cell cohorts, PPIAL4E RNA expression is significantly associated with the go_rna of many other GO terms, with 266 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPIAL4E-associated GO terms across cancer lineages are Glutamate receptor signaling pathway, Positive regulation of dendritic spine maintenance, and Neuromuscular process controlling balance. Each is linked with PPIAL4E in more than 2 cancer types. Because this analysis shows association rather than direction, both PPIAL4E-to-partner and partner-to-PPIAL4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glutamate receptor signaling pathway grouped by PPIAL4E-low versus PPIAL4E-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIAL4E→partner) and Y-score (partner→PPIAL4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Glutamate receptor signaling pathway →	-0.053	-0.024	.009	.004	3	3
KIDNEY	Positive regulation of dendritic spine maintenance →	-0.500	-0.042	<.001	.004	3	2
LUNG_NSCLC_LUAD	Neuromuscular process controlling balance →	-0.097	-0.017	.009	.007	3	2
CNS	Cholesterol biosynthetic process via desmosterol →	+0.094	+0.020	.008	.004	3	2
KIDNEY	Regulation of cell junction assembly →	-0.056	-0.027	.002	.009	3	2
KIDNEY	Negative regulation of protein-containing complex disassembly →	-0.072	-0.027	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 266 associations by consensus.

Glutamate receptor signaling pathway by PPIAL4E expression — PANCREAS

Explore this box plot interactively →