PPIAL4D

Across TCGA patient cohorts, PPIAL4D mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIAL4D-associated genes across cancer lineages are MIR133B, SNORD115-9, and MIR1258. Each is linked with PPIAL4D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIAL4D-to-partner and partner-to-PPIAL4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR133B grouped by PPIAL4D-low versus PPIAL4D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIAL4D→partner) and Y-score (partner→PPIAL4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR133B →	+0.356	+8.066	<.001	.007	3	1
UCEC	SNORD115-9 →	+0.612	+8.066	<.001	.007	3	1
UCEC	MIR1258 →	+0.509	+8.066	<.001	.007	3	1
UCEC	FAM243A →	+0.069	+8.066	<.001	.007	3	1
UCEC	RNU7-95P →	+0.562	+8.066	<.001	.007	3	1
SKCM	RN7SL601P →	+0.249	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MIR133B by PPIAL4D expression — UCEC

Explore this box plot interactively →