PPIAL4D

Across TCGA pan-cancer cohorts, PPIAL4D RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated PPIAL4D data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPIAL4D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPIAL4D expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

HNSC, THYM, and KIRC are the cancer types where PPIAL4D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.238	0.399	.001	87	view →
THYM	OS	Tertile	All	0.906	0.990	<.001	75	view →
KIRC	DFS	Tertile	III,IV	0.397	0.682	.001	72	view →
UCS	DFS	Tertile	IV	0.230	0.767	.009	36	view →
MESO	OS	Tertile	III,IV	0.290	0.589	.022	36	view →
BLCA	DFS	Tertile	IV	0.160	0.523	<.001	24	view →
UCEC	DFS	Tertile	All	0.811	0.906	.003	18	view →
STAD	DFS	Quartile	All	0.200	0.484	.007	12	view →
DLBC	OS	Tertile	IV	0.147	1.000	.045	9	view →
SKCM	OS	Tertile	All	0.843	0.763	.014	9	view →
READ	DFS	Tertile	All	0.706	0.500	.026	9	view →
LUAD	DFS	Quartile	All	0.536	0.692	.014	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

PPIAL4D–HNSC (OS)

Open the HNSC breakdown →