PPIAL4C

Across TCGA patient cohorts, PPIAL4C mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PPIAL4C-associated genes across cancer lineages are MIR5787, OR9I1, and TRIM60. Each is linked with PPIAL4C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIAL4C-to-partner and partner-to-PPIAL4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5787 grouped by PPIAL4C-low versus PPIAL4C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIAL4C→partner) and Y-score (partner→PPIAL4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR5787 →	+0.401	+4.513	<.001	.009	3	2
SKCM	OR9I1 →	+0.033	+5.624	<.001	.002	3	1
SKCM	TRIM60 →	+0.740	+4.268	<.001	.008	3	1
SKCM	RNU6-454P →	+0.233	+4.594	<.001	.008	3	1
SKCM	RNU6-438P →	+0.733	+4.296	.003	.008	3	1
SKCM	MIR520C →	+0.443	+5.080	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MIR5787 by PPIAL4C expression — SKCM

Explore this box plot interactively →