PPIAL4C

Across TCGA pan-cancer cohorts, PPIAL4C RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PPIAL4C data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPIAL4C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPIAL4C expression acts as an unfavorable survival marker, although some lineages such as CESC and THCA show a favorable association.

KIRP, ACC, and HNSC are the cancer types where PPIAL4C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.850	0.942	.004	50	view →
ACC	OS	Median	All	0.798	0.932	.003	47	view →
HNSC	DFS	Quartile	All	0.597	0.758	<.001	46	view →
LIHC	DFS	Tertile	III,IV	0.170	0.426	.001	46	view →
MESO	OS	Median	IV	0.264	0.759	.002	27	view →
GBM	OS	Tertile	All	0.313	0.499	<.001	27	view →
READ	OS	Median	III,IV	0.447	1.000	.003	21	view →
STAD	OS	Tertile	All	0.667	0.864	.025	18	view →
CESC	OS	Median	II,III,IV	0.693	0.400	.016	18	view →
BRCA	DFS	Quartile	II,III,IV	0.927	0.952	.015	11	view →
THYM	DFS	Tertile	IV	0.407	1.000	.026	9	view →
THCA	DFS	Median	All	0.916	0.766	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PPIAL4C–KIRP (DFS)

Open the KIRP breakdown →