PPEF2

Across TCGA cell cohorts, PPEF2 mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPEF2-associated genes across cancer lineages are F9, LUZP4, and FAM149A. Each is linked with PPEF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPEF2-to-partner and partner-to-PPEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by PPEF2-low versus PPEF2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPEF2→partner) and Y-score (partner→PPEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	F9 →	+0.027	+4.643	<.001	.004	3	1
LUNG_SCLC	LUZP4 →	+1.000	+4.044	<.001	.009	3	1
LARGE_INTESTINE	FAM149A →	+1.502	+3.364	<.001	.002	3	1
LARGE_INTESTINE	C12orf65 →	+0.477	+3.064	.002	.009	3	1
LARGE_INTESTINE	CAPN7 →	+0.578	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PPP1R9A →	+1.088	+3.364	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

F9 by PPEF2 expression — LUNG_SCLC

Explore this box plot interactively →