PPEF2

Across TCGA pan-cancer cohorts, PPEF2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPEF2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PPEF2 RNA is repressed in tumor relative to normal tissue. In most cancer types PPEF2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, KIRC, and PRAD are the cancer types where PPEF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPEF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.032	<.001	9	view →
KIRC	Male	All	+0.026	<.001	6	view →
PRAD	All	All	+0.029	<.001	2	view →
COAD	Female	IV	+0.105	.019	1	view →
LUSC	Female	All	−0.025	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPEF2–KICH

Open the KICH breakdown →