PPARGC1A

Across TCGA patient cohorts, PPARGC1A protein abundance is significantly associated with the RNA expression of many other genes, with 1,210 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPARGC1A-associated genes across cancer lineages are LGALS1, CERK, and PLEK2. Each is linked with PPARGC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPARGC1A-to-partner and partner-to-PPARGC1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPARGC1A versus LGALS1 in GBM, with a Pearson correlation of -0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARGC1A→partner) and Y-score (partner→PPARGC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LGALS1 →	-1.368	-0.789	.005	.002	3	1
GBM	CERK →	-0.490	-0.719	.001	<.001	3	1
GBM	PLEK2 →	-0.746	-0.809	.003	<.001	3	1
GBM	SEC23A →	-0.657	-0.679	.007	.005	3	1
GBM	BMP7 →	+1.743	+0.855	.001	.007	3	1
GBM	TIMP1 →	-2.316	-0.638	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,210 associations by consensus.

PPARGC1A vs LGALS1 — GBM

Explore this scatter interactively →