PPARGC1A

Across TCGA patient cohorts, PPARGC1A mutation is significantly associated with the RNA expression of many other genes, with 3,235 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPARGC1A-associated genes across cancer lineages are CDKN3, WRAP53, and EME1. Each is linked with PPARGC1A in more than 4 cancer types. Because this analysis shows association rather than direction, both PPARGC1A-to-partner and partner-to-PPARGC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by PPARGC1A-low versus PPARGC1A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARGC1A→partner) and Y-score (partner→PPARGC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CDKN3 →	+0.744	+3.471	.001	.002	3	5
UCEC	WRAP53 →	+0.308	+1.745	.003	.004	3	5
LUAD	EME1 →	+0.776	+3.459	.003	.005	3	5
UCEC	CHAF1B →	+0.438	+1.502	<.001	.001	3	5
LUSC	NDUFA8 →	+0.529	+3.348	<.001	.005	3	4
UCEC	HAUS8 →	+0.294	+1.847	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,235 associations by consensus.

CDKN3 by PPARGC1A expression — LUSC

Explore this box plot interactively →