PPARGC1A

Across TCGA cell cohorts, PPARGC1A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,070 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PPARGC1A-associated GO terms across cancer lineages are Aerobic respiration, Macroautophagy, and Aerobic electron transport chain. Each is linked with PPARGC1A in more than 8 cancer types. Because this analysis shows association rather than direction, both PPARGC1A-to-partner and partner-to-PPARGC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aerobic respiration grouped by PPARGC1A-low versus PPARGC1A-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARGC1A→partner) and Y-score (partner→PPARGC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Aerobic respiration →	+0.068	+0.859	<.001	.004	3	9
LUNG_SCLC	Macroautophagy →	+0.032	+1.535	.004	<.001	3	9
CNS	Aerobic electron transport chain →	+0.059	+1.050	.001	.001	3	9
SKIN	Endosomal lumen acidification →	+0.120	+1.360	<.001	.008	3	8
LUNG_SCLC	Regulation of autophagosome assembly →	+0.045	+1.657	.002	<.001	3	7
CNS	Process utilizing autophagic mechanism →	+0.034	+1.216	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,070 associations by consensus.

Aerobic respiration by PPARGC1A expression — OVARY

Explore this box plot interactively →